R/S and E/Z labels

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• Yes, according to the manual: Computed R/S and E/Z indicators update with drawing changes. Opens the cited page.ChemDrawComputed R/S and E/Z indicators update with drawing changes.
• Yes, according to the manual: Computes tetrahedral R/S and ordinary alkene E/Z descriptors. Opens the cited page.ReShikiUses Ported from RDKit CIPLabeler and SiMolecule centres (Rust). Computes tetrahedral R/S and ordinary alkene E/Z descriptors.Source
• Yes, according to the manual: Computed CIP labels include R, S, E, and Z. Opens the cited page.MolDrawUses In-house browser JavaScript CIP/E-Z perception; Indigo 1.46.0 browser WebAssembly fallback. Computed CIP labels include R, S, E, and Z.Source
• Yes, according to the manual: Computes CIP R/S and E/Z labels from drawings. Opens the cited page.PenzeneUses RDKit CIPLabeler (C++). Computes CIP R/S and E/Z labels from drawings.Source
• Yes, according to the manual: Computes R/S/r/s and E/Z with its own CIP labeller. Opens the cited page.Octet DrawUses In-house (TypeScript CIP and axial stereochemistry labellers). Computes R/S/r/s and E/Z with its own CIP labeller.Source
• Yes, according to the manual: Computed R/S and E/Z descriptors. Opens the cited page.ChemDraftUses RDKit MinimalLib (WebAssembly R/S and E/Z analysis) + OpenChemLib (JavaScript editor stereo perception). Computed R/S and E/Z descriptors.Source
• Yes, according to the manual. Opens the cited page.ChemEditUses Indigo 1.45.1 (C++ compiled to WebAssembly, calculateCip through ketcher-standalone 3.17.2). Source
• Yes, according to the manual. Opens the cited page.Chem IllustratorUses RDKit MinimalLib 2026.9.1 (WebAssembly CIP R/S and E/Z perception); In-house (TypeScript drawing interpretation and generic-group handling). Source
• Yes, according to the manual: Calculate CIP returns atom R/S and bond E/Z descriptors. Opens the cited page.ChemThisTryUses Indigo (WebAssembly via ketcher-standalone). Calculate CIP returns atom R/S and bond E/Z descriptors.Source
• Yes, according to the manual: Computes R/S and E/Z; ambiguous assignments are omitted. Opens the cited page.Chematic DrawUses In-house (chematic-chem, Rust/WebAssembly assign_cip R/S and E/Z). Computes R/S and E/Z; ambiguous assignments are omitted.Source
• Yes, according to the manual: RDKit computes R/S and E/Z overlays. Opens the cited page.Molecule Lab (The Freshman Mole)Uses RDKit.js (WebAssembly); In-house (JavaScript geometry-based E/Z preview). RDKit computes R/S and E/Z overlays.Source
• Yes, according to the manual: Embedded Ketcher computes R/S, r/s and E/Z descriptors. Opens the cited page.FreeChemDrawUses Indigo (WebAssembly CIP calculation through Ketcher). Embedded Ketcher computes R/S, r/s and E/Z descriptors.Source
• Yes, according to the manual: Assigns R/S centers and E/Z double bonds. Opens the cited page.MolChartUses OpenChemLib (browser JavaScript cHelperCIP, getAtomCIPParity and getBondCIPParity). Assigns R/S centers and E/Z double bonds.Source
• Yes, according to the manual: Ketcher computes R/S, r/s and E/Z descriptors. Opens the cited page.KendrawUses Indigo (indigo-ketcher 1.40.0 WebAssembly through Ketcher 3.12.0). Ketcher computes R/S, r/s and E/Z descriptors.Source
• Yes, according to the manual: Calculate CIP determines R/S and E/Z. Opens the cited page.BoltzDrawUses Indigo (WebAssembly). Calculate CIP determines R/S and E/Z.Source
• Yes, according to the manual: Ketcher computes R/S, r/s, and E/Z descriptors. Opens the cited page.MolbrettUses Indigo 1.46.0 (WebAssembly, Ketcher standalone browser worker). Ketcher computes R/S, r/s, and E/Z descriptors.Source
• Yes, according to the manual: Computes R/S centers and E/Z double-bond descriptors. Opens the cited page.Zeanium Molecule DrawerUses In-house (JavaScript, browser). Computes R/S centers and E/Z double-bond descriptors.Source
• Yes, according to the manual: R/S and E/Z resolution through iChemLabs Cloud Services. Opens the cited page.ChemDoodle Web ComponentsUses ChemDoodle Java API (remote iChemLabs CloudServices; resolveCIP). R/S and E/Z resolution through iChemLabs Cloud Services.Source
• Yes, according to the manual: Ketcher calculates R/S, r/s and E/Z descriptors. Opens the cited page.Chemeditor (Chemrise)Uses Indigo (WebAssembly through ketcher-standalone, calculateCip). Ketcher calculates R/S, r/s and E/Z descriptors.Source
• Yes, according to the manual: Computes R/S and E/Z; checks converted stereochemistry. Opens the cited page.MoleditPyUses RDKit (Python Chem stereochemistry and rdCIPLabeler). Computes R/S and E/Z; checks converted stereochemistry.Source
• Yes, according to the manual: Calculate CIP assigns R/S, r/s and E/Z descriptors. Opens the cited page.KetcherUses Indigo C++ CIP calculation (indigo-ketcher WebAssembly or Indigo HTTP service). Calculate CIP assigns R/S, r/s and E/Z descriptors.Source
• Yes, according to the manual: Calculate CIP determines R/S, r/s and E/Z configurations. Opens the cited page.AI Chemical Drawing (CubicZnS)Uses Indigo 1.46.0 (WebAssembly). Calculate CIP determines R/S, r/s and E/Z configurations.Source
• Yes, according to the manual: Calculate CIP assigns R/S and E/Z. Opens the cited page.KetchDrawUses Indigo (WebAssembly). Calculate CIP assigns R/S and E/Z.Source
• Yes, according to the manual: R/S labels for tetrahedral carbons require four explicit substituents. Opens the cited page.cDrawUses Ported from CDK 2.0 CIPTool/stereo (Java), with in-house CalculateCIPchirality. R/S labels for tetrahedral carbons require four explicit substituents.Source
• Yes, according to the manual: Automatic R/S labels; alkene geometry encoded in isomeric SMILES. Opens the cited page.BondCraftUses In-house. Automatic R/S labels; alkene geometry encoded in isomeric SMILES.Source
• Partly: Legacy-layout R/S labels; no E/Z label rendering. Opens the cited page.Molsoft HTML5 Molecule EditorUses In-house (Molsoft libchem, WebAssembly; asm.js fallback); R/S labels only. Legacy-layout R/S labels; no E/Z label rendering.Source
• Partly: R/S from wedges; E/Z requires imported directional semantics. Opens the cited page.ChemSemaUses In-house (Rust chemsema-chemistry CIP and stereo analysis). R/S from wedges; E/Z requires imported directional semantics.Source
• Partly: Computes parity instead of R/S or E/Z descriptors. Opens the cited page.Kekule.jsComputes parity instead of R/S or E/Z descriptors.Source
• Yes, according to the manual: Molecule.java computes chirality; editor displays R/S and E/Z. Opens the cited page.SketchElUses In-house. Molecule.java computes chirality; editor displays R/S and E/Z.Source
• Partly: Limited R/S console output; four-neighbor stereocenters remain unfinished. Opens the cited page.ChemCanvasJSUses In-house. Limited R/S console output; four-neighbor stereocenters remain unfinished.Source
• Yes, according to the manual: Computes MCDL stereodescriptors; standard R/S and E/Z labels unverified. Opens the cited page.MCDL Java Chemical Structure EditorUses In-house. Computes MCDL stereodescriptors; standard R/S and E/Z labels unverified.Source
• Yes, according to the manual. Opens the cited page.ChemDoodle 2DUses CENTRES by John May (bundled Java library for CIP descriptors). Source
• Yes, according to the manual: Native stereo tags and Indigo CIP fallback supply R/S and E/Z. Opens the cited page.LabCanvas Figure Editor / MolDrawUses In-house (JavaScript R/S and E/Z assignment); Indigo (WebAssembly calculateCip fallback). Native stereo tags and Indigo CIP fallback supply R/S and E/Z.Source
• Yes, according to the manual. Opens the cited page.Marvin Desktop Suite / MarvinSketchSource
• Yes, according to the manual: Automatically computes atom R/S and bond E/Z descriptors. Opens the cited page.ChemDraft (元素智研)Automatically computes atom R/S and bond E/Z descriptors.Source
• Partly: R/S computed; E/Z unverified. Opens the cited page.InDrawUses RDKit.js (browser WebAssembly get_stereo_tags); RDKit (desktop rdkitAPI.getStereoTags IPC). R/S computed; E/Z unverified.Source
• Yes, according to the manual: R/S and E/Z calculation requires web services. Opens the cited page.Marvin JSUses In-house Chemaxon CIP Stereo Info (remote Java REST service via MJSWS, JChem Web Services or JChem Microservices; stereoinfows). R/S and E/Z calculation requires web services.Source
• Yes, according to the manual: Computed tetrahedral labels and enhanced E/Z stereochemistry. Opens the cited page.BIOVIA DrawUses In-house BIOVIA NEMA algorithm (built-in stereochemistry recognition). Computed tetrahedral labels and enhanced E/Z stereochemistry.Source
• Yes, according to the manual: R/S and E/Z recognition; vendor claim. Opens the cited page.ChemWindow (KnowItAll ChemWindow Edition)R/S and E/Z recognition; vendor claim.Source
• Yes, according to the manual: Calculates R/S, r/s and E/Z descriptors. Opens the cited page.Chemistry DrawUses Indigo (native C++ via Rust FFI; indigoAddCIPStereoDescriptors). Calculates R/S, r/s and E/Z descriptors.Source
• Yes, according to the manual: R/S and E/Z stereo annotations. Opens the cited page.Zoho ChemStudioR/S and E/Z stereo annotations.Source
• Yes, according to the manual: Paid stereochemistry; Windows Professional adds E/Z labeling. Opens the cited page.KingDrawEducation 4.0 (university email)Paid stereochemistry; Windows Professional adds E/Z labeling.Source
• Yes, according to the manual: Computed R/S and E/Z appear in generated names. Opens the cited page.ChemPencilComputed R/S and E/Z appear in generated names.Source
• Yes, according to the manual: Computed CIP R/S and E/Z labels. Opens the cited page.Marvin CloudUses In-house Marvin Web Services CIP calculation (remote Java service). Computed CIP R/S and E/Z labels.Source
• Yes, according to the manual: Vendor claim: R/S all editions; E/Z naming Pro/Office. Opens the cited page.Chemistry 4-D DrawUses In-house (Nomenclator desktop module). Vendor claim: R/S all editions; E/Z naming Pro/Office.Source
• Yes, according to the manual: R/S labels follow wedge/hash stereochemistry; vendor claim. Opens the cited page.Elk_Draw RDKitR/S labels follow wedge/hash stereochemistry; vendor claim.Source
• Yes, according to the manual: Computes R/S and E/Z labels locally. Opens the cited page.MolPrime+Uses MMDS core library (Objective-C, local). Computes R/S and E/Z labels locally.Source
• Yes, according to the manual: Automatically assigns CIP descriptors. Opens the cited page.ChemScribbleUses ChemDoodle engine (embedded in Java desktop application). Automatically assigns CIP descriptors.Source

Not available

• No: No R/S or E/Z assignment. Opens the cited page.ErezDrawNo R/S or E/Z assignment.Source
• No: R/S and E/Z support is listed as future work. Opens the cited page.Molecule Builder (OvOHongYu)R/S and E/Z support is listed as future work.Source
• No: Absent from v2.0.1; implemented in newer unreleased source. Opens the cited page.XDrawChemAbsent from v2.0.1; implemented in newer unreleased source.Source
• No: Stereochemical inference explicitly dropped; authored depiction remains. Opens the cited page.Ferrum Chemical ForgeStereochemical inference explicitly dropped; authored depiction remains.Source
• No: E/Z labels are manually assigned; no computed stereodescriptors. Opens the cited page.BondDrawE/Z labels are manually assigned; no computed stereodescriptors.Source