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RXN files
MDL RXN files can be read or written.
52 tools have this, 5 of them shown here. 6 do not. 70 not established.
- Tested by running it
- Seen in the app
- The manual says yes
- Partly, with the reason shown
- Not supported
- Not established, which is not the same as no
Select a mark for its proof. A filled mark opens our screenshot, or the manual if the check left nothing to picture. A ring opens the manual.

Yes, according to the manual: RXN import/export uses explicitly defined reaction roles. ReShiki
0.14.0
Reaction roles panel includes an RXN V3000 export option.

Yes, according to the manual: MDL RXN reaction export. MolDraw
4.0
Download menu lists RXN among chemistry formats.

Yes, according to the manual SketchIQ
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Reaction panel lists RXN among the export formats.

Yes, according to the manual: Embedded Ketcher reads and writes MDL RXN reactions. FreeChemDraw
3.18.0
Save Structure dialog with MDL Rxnfile V2000 selected.

Yes, according to the manual: Reads RXN; molFile exports RXN for reaction drawings. JSME Molecule Editor
v2024-04-29
Reaction menu offers RXN copy and paste commands.
Available, no screenshot
ChemDraw's license keeps us from publishing pictures of its interface.
- Yes, according to the manual: Reads and writes RXN V2000/V3000; all editions. Opens the cited page.ChemDrawReads and writes RXN V2000/V3000; all editions.Source
- Yes, according to the manual. Opens the cited page.PenzeneSource
- Yes, according to the manual: Reads and writes V2000 and V3000 RXN reactions. Opens the cited page.Octet DrawReads and writes V2000 and V3000 RXN reactions.Source
- Partly: RXN paste extracts molecules; reaction roles, arrows and layout are omitted. Opens the cited page.ChemDraftRXN paste extracts molecules; reaction roles, arrows and layout are omitted.Source
- Yes, according to the manual: Open and export RXN reaction files. Opens the cited page.CovalentOpen and export RXN reaction files.Source
- Yes, according to the manual. Opens the cited page.Reactio DrawSource
- Yes, according to the manual. Opens the cited page.ChemEditSource
- Yes, according to the manual. Opens the cited page.Chem IllustratorSource
- Yes, according to the manual: RXN file import is documented. Opens the cited page.ChemThisTryRXN file import is documented.Source
- Yes, according to the manual: One-step RXN V2000; agents and coefficients require loss confirmation. Opens the cited page.Chematic DrawOne-step RXN V2000; agents and coefficients require loss confirmation.Source
- Yes, according to the manual: Read/write; export requires exactly one reaction. Opens the cited page.vibe-sketcherRead/write; export requires exactly one reaction.Source
- Yes, according to the manual: Ketcher reads and writes RXN V2000/V3000. Opens the cited page.KendrawKetcher reads and writes RXN V2000/V3000.Source
- Yes, according to the manual: Native Ketcher exports RXN V2000 and V3000. Opens the cited page.BoltzDrawNative Ketcher exports RXN V2000 and V3000.Source
- Partly: RXN preview generated for a drawing with arrows. Opens the cited page.MolbrettRXN preview generated for a drawing with arrows.Source
- Partly: Reaction mode saved RXN; import not checked. Opens the cited page.Sciformation VectorMolReaction mode saved RXN; import not checked.Source
- Yes, according to the manual: Export only; README's read/write claim exceeds implemented support. Opens the cited page.BondForgeExport only; README's read/write claim exceeds implemented support.Source
- Yes, according to the manual: Native readRXN and writeRXN APIs. Opens the cited page.ChemDoodle Web ComponentsNative readRXN and writeRXN APIs.Source
- Yes, according to the manual: Ketcher loads and saves MDL RXN reactions. Opens the cited page.Chemeditor (Chemrise)Ketcher loads and saves MDL RXN reactions.Source
- Yes, according to the manual: RXN V2000 and V3000. Opens the cited page.KetcherRXN V2000 and V3000.Source
- Yes, according to the manual: AI-generated RXN input and Copy RXN export. Opens the cited page.AI Chemical Drawing (CubicZnS)AI-generated RXN input and Copy RXN export.Source
- Yes, according to the manual: Single reaction arrow required; agent structures rejected on import. Opens the cited page.OpenReactionsSingle reaction arrow required; agent structures rejected on import.Source
- Yes, according to the manual: Source checkout; RXN V2000 export. Opens the cited page.Molecule Builder (OvOHongYu)Source checkout; RXN V2000 export.Source
- Yes, according to the manual. Opens the cited page.KetchDrawSource
- Yes, according to the manual: RXN import and V3000 export. Opens the cited page.Schrödinger SketcherRXN import and V3000 export.Source
- Partly: Open Babel 3 imports components; reaction roles and mapping are discarded. Opens the cited page.MolsketchOpen Babel 3 imports components; reaction roles and mapping are discarded.Source
- Yes, according to the manual: Reads and writes MDL RXN reaction files. Opens the cited page.JChemPaintReads and writes MDL RXN reaction files.Source
- Yes, according to the manual: API reads and writes RXN V2000 and V3000. Opens the cited page.OpenChemLib JS editorAPI reads and writes RXN V2000 and V3000.Source
- Partly: RXN text output generated; RXN import not tested. Opens the cited page.Dotmatics Elemental / Elemental DrawRXN text output generated; RXN import not tested.Source
- Yes, according to the manual: Reads and writes RXN2000 and RXN3000. Opens the cited page.Kekule.jsReads and writes RXN2000 and RXN3000.Source
- Yes, according to the manual: Reads and writes MDL RXN reaction data. Opens the cited page.Ketcherails (ketcher-rails)Reads and writes MDL RXN reaction data.Source
- Yes, according to the manual: RXN reading and writing through JavaScript API. Opens the cited page.KemiaRXN reading and writing through JavaScript API.Source
- Partly: RXN listed in import and export menus. Opens the cited page.SketChemRXN listed in import and export menus.
- Yes, according to the manual. Opens the cited page.ChemDoodle 2DSource
- Yes, according to the manual: Indigo import/export; reaction layout fidelity unverified; Pro downloads. Opens the cited page.LabCanvas Figure Editor / MolDrawIndigo import/export; reaction layout fidelity unverified; Pro downloads.Source
- Yes, according to the manual. Opens the cited page.Marvin Desktop Suite / MarvinSketchSource
- Yes, according to the manual: RXN export requires web services. Opens the cited page.Marvin JSRXN export requires web services.Source
- Yes, according to the manual: vendor claim; saves RXN reactions with reagent information. Opens the cited page.BIOVIA Drawvendor claim; saves RXN reactions with reagent information.Source
- Yes, according to the manual: Supports MDL RXN and RXN V3000 files. Opens the cited page.ChemWindow (KnowItAll ChemWindow Edition)Supports MDL RXN and RXN V3000 files.Source
- Partly: Native automapping supports RXN; ordinary conversion uses a molecule loader. Opens the cited page.Chemistry DrawNative automapping supports RXN; ordinary conversion uses a molecule loader.Source
- Yes, according to the manual: Imported RXN files are explicitly listed. Opens the cited page.Zoho ChemStudioImported RXN files are explicitly listed.Source
- Yes, according to the manual: RXN read/write; vendor claim. Opens the cited page.ChemPencilRXN read/write; vendor claim.Source
- Yes, according to the manual: Vendor claim: RXN import and export. Opens the cited page.ACD/ChemSketchVendor claim: RXN import and export.Source
- Yes, according to the manual: RXN export is documented. Opens the cited page.Marvin CloudRXN export is documented.Source
- Yes, according to the manual: MDL RXN input and whole-reaction export. Opens the cited page.AtomLensMDL RXN input and whole-reaction export.Source
- Yes, according to the manual: RXN import/export, including V3000 output. Opens the cited page.JSDrawRXN import/export, including V3000 output.Source
- Yes, according to the manual: MDL RXN import and export in reaction mode. Opens the cited page.ChemStitchFreeMDL RXN import and export in reaction mode.Source
- Yes, according to the manual: Vendor claim: RXN/RD export. Opens the cited page.Chirys DrawVendor claim: RXN/RD export.Source
Not available
- No: RXN absent from inspected file-format lists. Opens the cited page.ChemCanvasRXN absent from inspected file-format lists.
- No: RXN interchange is listed as future work. Opens the cited page.XDrawChemRXN interchange is listed as future work.Source
- No: Reaction CTfiles are unsupported. Opens the cited page.ChemifreeReaction CTfiles are unsupported.Source
- No: File handlers support MOL and SMILES only. Opens the cited page.rdEditorFile handlers support MOL and SMILES only.Source
- No: RXN reaction files explicitly unsupported. Opens the cited page.BondDrawRXN reaction files explicitly unsupported.Source
- No: Chemical file import and export are unavailable. Opens the cited page.ChemScribbleChemical file import and export are unavailable.Source
Not established (70)
Molecule Lab (The Freshman Mole), ErezDraw, MolChart, MolCanvas, Chemliora, Zeanium Molecule Drawer, MoleditPy, MolView.com, PyChem-Pro, chemfig, Chemvas, Chemable, WaveSpeed AI Chemical Structure Drawer, cDraw, BondCraft, Molsoft HTML5 Molecule Editor, Molecule Clipboard, MolGLideX, SketchScape, ChemSema, Structura (chem-structura), MolSketch, SketchEl 2, SketchEl, RadSketch, Butlerov, schematic, ChemMD, WebMolKit, ChemCanvasJS, Chemical Structure Editor (CSE), JMolDraw, MolTouch, Chemeditor (Chemie-Lernprogramme), vue-chemdraw (0chem), ChemWriter, MCDL Java Chemical Structure Editor, Glass, molsketch-cljs, MolPad, BKChem Python 3 Modernized, ChemDraft (元素智研), InDraw, BKChem, GChemPaint, KingDraw, Ferrum Chemical Forge, Chem4Word, Chemtool, Lhendraw, ChemCAD, MoleculeSketch, FX ChemStruct / FX Draw Chemical Structures, Chemistry 4-D Draw, ChemGraphic 2, EasyChem, MolSketchGo, MyChemise, CyBy-Draw, Elk_Draw RDKit, Chem+ Molecular Structure Editor, MolPrime+, MolGenDraw, Chem Sketcher (Non_REM.Persona Laboratory), Structo, Chemograph Plus, alvaSketcher, moled, ChemWorks, Molecule