CDX import and export

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• Yes, according to the manual: Reads and writes native binary CDX; all editions. Opens the cited page.ChemDrawReads and writes native binary CDX; all editions.Source
• Yes, according to the manual: Binary CDX import and export on every desktop platform. Opens the cited page.PenzeneUses Revvity ChemDraw file library (Glysade/chemdraw, vendored C++ private static library). Binary CDX import and export on every desktop platform.Source
• Yes, according to the manual: Native CDX reader and writer preserve drawing objects. Opens the cited page.Octet DrawUses In-house (TypeScript CDX binary reader and writer sharing the CDXML object tree). Native CDX reader and writer preserve drawing objects.Source
• Yes, according to the manual. Opens the cited page.Reactio DrawUses In-house JavaScript binary CDX reader/writer; ReShiki CDX property-table data, with no ReShiki runtime code. Source
• Yes, according to the manual: Use Ketcher's own file dialogs. Opens the cited page.ChemEditUses Indigo 1.45.1 (C++ compiled to WebAssembly, CDX import/export through Ketcher 3.17.2). Use Ketcher's own file dialogs.Source
• Yes, according to the manual. Opens the cited page.Chem IllustratorUses In-house (TypeScript binary CDX codec converting to/from CDXML). Source
• Partly: CDX import documented; export unverified. Opens the cited page.ChemThisTryUses Indigo (WebAssembly CDX import via ketcher-standalone). CDX import documented; export unverified.Source
• Partly: Imports binary CDX; no CDX export. Opens the cited page.vibe-sketcherUses In-house Python CDX-to-CDXML translator + RDKit Python parser (import only). Imports binary CDX; no CDX export.Source
• Partly: Imports supported objects; no CDX export or lossless round trip. Opens the cited page.ErezDrawUses In-house (Python struct-based binary CDX parser; import only). Imports supported objects; no CDX export or lossless round trip.Source
• Yes, according to the manual. Opens the cited page.MolChartSource
• Yes, according to the manual: Binary and base64 CDX via Ketcher's Open/Save. Opens the cited page.KendrawUses Indigo (indigo-ketcher 1.40.0 WebAssembly through Ketcher 3.12.0). Binary and base64 CDX via Ketcher's Open/Save.Source
• Yes, according to the manual: Native Ketcher supports binary and base64 CDX. Opens the cited page.BoltzDrawUses Indigo (WebAssembly). Native Ketcher supports binary and base64 CDX.Source
• Partly: Import only. Opens the cited page.ChemlioraUses In-house (JavaScript binary CDX parser; import only). Import only.Source
• Yes, according to the manual: Structure import/export through Ketcher; whiteboards use Excalidraw format. Opens the cited page.MolbrettUses Indigo 1.46.0 (WebAssembly, Ketcher standalone browser worker). Structure import/export through Ketcher; whiteboards use Excalidraw format.Source
• Yes, according to the manual: Read/write through iChemLabs Cloud Services using desktop-format support. Opens the cited page.ChemDoodle Web ComponentsUses ChemDoodle Java API (remote iChemLabs CloudServices; getMoleculeFromContent and saveFile format conversion). Read/write through iChemLabs Cloud Services using desktop-format support.Source
• Yes, according to the manual: Ketcher supports binary CDX and Base64 CDX. Opens the cited page.Chemeditor (Chemrise)Uses Indigo (WebAssembly through ketcher-standalone). Ketcher supports binary CDX and Base64 CDX.Source
• Yes, according to the manual. Opens the cited page.KetcherUses Indigo C++ conversion (indigo-ketcher WebAssembly or Indigo HTTP service). Source
• Yes, according to the manual: Embedded Ketcher reads and writes binary CDX. Opens the cited page.AI Chemical Drawing (CubicZnS)Uses Indigo 1.46.0 (WebAssembly). Embedded Ketcher reads and writes binary CDX.Source
• Yes, according to the manual: Binary CDX import; binary and Base64 CDX export. Opens the cited page.KetchDrawUses Indigo (WebAssembly). Binary CDX import; binary and Base64 CDX export.Source
• Partly: CDX import listed; no CDX save format listed. Opens the cited page.MolsketchCDX import listed; no CDX save format listed.
• Yes, according to the manual. Opens the cited page.ChemSemaUses In-house (Rust CDX binary reader and writer through CDXML conversion). Source
• Partly: Reads binary CDX; saving uses CDXML instead. Opens the cited page.XDrawChemUses In-house (C++ CDX-to-CDXML binary parser; import only). Reads binary CDX; saving uses CDXML instead.Source
• Partly: Bounded codec; edited drawings cannot be exported as CDX. Opens the cited page.ChemifreeUses In-house (Rust CDX binary reader and writer; interchange-tree export). Bounded codec; edited drawings cannot be exported as CDX.Source
• Partly: CDX listed for import, not export. Opens the cited page.SketChemUses Open Babel (WebAssembly via Kekule.js; import only). CDX listed for import, not export.
• Partly: ChemWriter 2 imports limited CDX; export API writes MOL only. Opens the cited page.ChemWriterUses In-house (JavaScript; CDX import only). ChemWriter 2 imports limited CDX; export API writes MOL only.Source
• Yes, according to the manual. Opens the cited page.ChemDoodle 2DUses In-house (ChemDoodle Java file-format interpreters, local). Source
• Yes, according to the manual: Indigo binary import/export; Pro downloads; fidelity untested. Opens the cited page.LabCanvas Figure Editor / MolDrawUses Indigo (WebAssembly binary CDX import/export conversion). Indigo binary import/export; Pro downloads; fidelity untested.Source
• Yes, according to the manual. Opens the cited page.Marvin Desktop Suite / MarvinSketchUses In-house Chemaxon I/O CDX module (local Java MolImporter/MolExporter). Source
• Yes, according to the manual: Import and export explicitly documented; clipboard exchange also supported. Opens the cited page.ChemDraft (元素智研)Import and export explicitly documented; clipboard exchange also supported.Source
• Yes, according to the manual. Opens the cited page.InDrawUses CDXConverter 1.0.0 (bundled JavaScript cdx2cdxml/cdxml2cdx); In-house (CDXML drawing-model mapping). Source
• Yes, according to the manual: Import and export require web services; binary import uses files. Opens the cited page.Marvin JSUses Chemaxon MolConvert (remote Java REST service via MJSWS, JChem Web Services or JChem Microservices; CDX import/export). Import and export require web services; binary import uses files.Source
• Partly: CDX import documented; export unverified. Opens the cited page.BIOVIA DrawCDX import documented; export unverified.Source
• Yes, according to the manual. Opens the cited page.GChemPaintUses In-house (C++ CDX loader plugin using Open Babel constants header). Source
• Yes, according to the manual. Opens the cited page.KingDrawSource
• Yes, according to the manual: Vendor claim: CDX import and export. Opens the cited page.ACD/ChemSketchVendor claim: CDX import and export.Source
• Yes, according to the manual: CDX is supported for export and template import. Opens the cited page.Marvin CloudUses In-house Marvin Web Services MolConvert (remote Java service). CDX is supported for export and template import.Source
• Yes, according to the manual: Reads and writes supported chemistry; arbitrary source metadata is lost. Opens the cited page.AtomLensReads and writes supported chemistry; arbitrary source metadata is lost.Source
• Yes, according to the manual: Binary CDX reading and writing. Opens the cited page.LhendrawUses In-house (C++ CDX binary parser/writer and internal-object conversion). Binary CDX reading and writing.Source
• Yes, according to the manual: Explicitly reads and writes CDX; vendor claim. Opens the cited page.Elk_Draw RDKitUses In-house (C# CDX reader/writer). Explicitly reads and writes CDX; vendor claim.Source

Not available

• No: Binary CDX is explicitly rejected; use CDXML. Opens the cited page.ChemDraftBinary CDX is explicitly rejected; use CDXML.Source
• No: Official comparison explicitly says CDX is not yet supported. Opens the cited page.CovalentOfficial comparison explicitly says CDX is not yet supported.Source
• No: Binary CDX import is explicitly rejected. Opens the cited page.Molecule Lab (The Freshman Mole)Binary CDX import is explicitly rejected.Source
• No: Binary CDX support is on the roadmap. Opens the cited page.MolCanvasBinary CDX support is on the roadmap.Source
• No: Legacy CDX support is described as future best-effort work. Opens the cited page.BondForgeLegacy CDX support is described as future best-effort work.Source
• No: CDX absent from inspected file-format lists. Opens the cited page.ChemCanvasCDX absent from inspected file-format lists.
• No: Binary CDX is explicitly unsupported. Opens the cited page.ChemvasBinary CDX is explicitly unsupported.Source
• No: Exporter writes only ChemMD source, SVG and PNG. Opens the cited page.ChemMDExporter writes only ChemMD source, SVG and PNG.Source
• No: File handlers support MOL and SMILES only. Opens the cited page.rdEditorFile handlers support MOL and SMILES only.Source
• No: Binary CDX input is explicitly refused. Opens the cited page.Ferrum Chemical ForgeBinary CDX input is explicitly refused.Source
• No: Binary CDX import unsupported; export remains on roadmap. Opens the cited page.ChemStitchBinary CDX import unsupported; export remains on roadmap.Source
• No: Only .scrb files can be opened or saved. Opens the cited page.ChemScribbleOnly .scrb files can be opened or saved.Source