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Peptides and nucleic acids
Sequence, HELM or monomer-based biomolecule tools.
34 tools have this, 2 of them shown here. 7 do not. 87 not established.
- Tested by running it
- Seen in the app
- The manual says yes
- Partly, with the reason shown
- Not supported
- Not established, which is not the same as no
Select a mark for its proof. A filled mark opens our screenshot, or the manual if the check left nothing to picture. A ring opens the manual.

Yes, according to the manual: Peptide sequences convert to structures, including D-residues and terminal modifications. BoltzDraw
Ketcher 2.24.0
Peptide import panel with sequence and terminal options.

Yes, tested by running it: Placed alanine monomer; amino-acid and nucleic-acid libraries visible. Schrödinger Sketcher
Release 2026-4 (build 131)
A monomer on the canvas beside amino acid and nucleic tabs.
Available, no screenshot
ChemDraw's license keeps us from publishing pictures of its interface.
- Yes, according to the manual: HELM peptide and oligonucleotide tools; Professional and Signals only. Opens the cited page.ChemDrawProfessionalHELM peptide and oligonucleotide tools; Professional and Signals only.Source
- Yes, according to the manual: Companion sequence tool builds peptide, DNA, and RNA structures. Opens the cited page.MolDrawCompanion sequence tool builds peptide, DNA, and RNA structures.Source
- Yes, according to the manual: Peptide sequences produce structures; supports D-residues and terminal caps. Opens the cited page.PenzenePeptide sequences produce structures; supports D-residues and terminal caps.Source
- Yes, according to the manual: Reads three-letter peptide sequences with D/L residues and terminal caps. Opens the cited page.Octet DrawReads three-letter peptide sequences with D/L residues and terminal caps.Source
- Yes, according to the manual: Ketcher sequence/macromolecule mode; complex sequences can fall back. Opens the cited page.ChemEditKetcher sequence/macromolecule mode; complex sequences can fall back.Source
- Yes, according to the manual: Peptide sequence input and biomolecule templates. Opens the cited page.Chem IllustratorPeptide sequence input and biomolecule templates.Source
- Partly: Nucleic-acid residue metadata editing; no sequence-to-structure builder established. Opens the cited page.Chematic DrawNucleic-acid residue metadata editing; no sequence-to-structure builder established.Source
- Yes, according to the manual: Embedded Ketcher supports peptides, nucleic acids, sequences and monomers. Opens the cited page.FreeChemDrawEmbedded Ketcher supports peptides, nucleic acids, sequences and monomers.Source
- Yes, according to the manual: Peptide, DNA, RNA sequence and HELM import/export. Opens the cited page.vibe-sketcherPeptide, DNA, RNA sequence and HELM import/export.Source
- Partly: Amino-acid and biomolecule template categories; no sequence editor seen. Opens the cited page.MolCanvasAmino-acid and biomolecule template categories; no sequence editor seen.
- Yes, according to the manual: Peptide, RNA/DNA, sequence and HELM tools. Opens the cited page.KendrawPeptide, RNA/DNA, sequence and HELM tools.Source
- Yes, tested by running it: IgG inserted; Sequence Editor and HELM export commands visible. Opens the cited page.BondForgeIgG inserted; Sequence Editor and HELM export commands visible.Source
- Yes, according to the manual: Ketcher supports peptides, nucleic acids, sequences and HELM. Opens the cited page.Chemeditor (Chemrise)Ketcher supports peptides, nucleic acids, sequences and HELM.Source
- Yes, according to the manual: Monomer library, sequence editing, FASTA and HELM. Opens the cited page.KetcherMonomer library, sequence editing, FASTA and HELM.Source
- Yes, according to the manual: Embedded Ketcher supports peptide and nucleic-acid monomers and sequences. Opens the cited page.AI Chemical Drawing (CubicZnS)Embedded Ketcher supports peptide and nucleic-acid monomers and sequences.Source
- Yes, according to the manual: Amino-acid and DNA/RNA monomer templates provide directional connection anchors. Opens the cited page.BondCraftAmino-acid and DNA/RNA monomer templates provide directional connection anchors.Source
- Yes, according to the manual: Paid platform edition: biological sequence editing; vendor claim. Opens the cited page.Dotmatics Elemental / Elemental DrawDotmatics ELNPaid platform edition: biological sequence editing; vendor claim.Source
- Partly: Amino-acid and nucleic-base templates; sequence builder does not assemble structures. Opens the cited page.XDrawChemAmino-acid and nucleic-base templates; sequence builder does not assemble structures.Source
- Yes, according to the manual: Official peptide-builder demo supplies amino-acid building blocks for manual assembly. Opens the cited page.JSME Molecule EditorOfficial peptide-builder demo supplies amino-acid building blocks for manual assembly.Source
- Yes, according to the manual: Builds structures from hyphenated amino acid or peptoid monomer sequences. Opens the cited page.Ketcherails (ketcher-rails)Builds structures from hyphenated amino acid or peptoid monomer sequences.Source
- Yes, according to the manual: Amino-acid sequence construction. Opens the cited page.ChemDoodle 2DAmino-acid sequence construction.Source
- Yes, according to the manual: Sequence builder opens peptides, DNA and RNA in MolDraw. Opens the cited page.LabCanvas Figure Editor / MolDrawSequence builder opens peptides, DNA and RNA in MolDraw.Source
- Yes, according to the manual: Imports peptide, DNA, and RNA sequences. Opens the cited page.Marvin Desktop Suite / MarvinSketchImports peptide, DNA, and RNA sequences.Source
- Yes, according to the manual. Opens the cited page.InDrawSource
- Yes, according to the manual: Typed peptide sequences, cyclic peptides and disulfide bridges. Opens the cited page.Marvin JSTyped peptide sequences, cyclic peptides and disulfide bridges.Source
- Yes, according to the manual: SCSR, HELM, and BILN support for modified biological sequences. Opens the cited page.BIOVIA DrawSCSR, HELM, and BILN support for modified biological sequences.Source
- Yes, according to the manual: Peptide and nucleic-acid monomer libraries and sequence editing. Opens the cited page.Chemistry DrawPeptide and nucleic-acid monomer libraries and sequence editing.Source
- Yes, according to the manual: Sequence tool accepts peptide, DNA, and RNA sequences. Opens the cited page.Zoho ChemStudioSequence tool accepts peptide, DNA, and RNA sequences.Source
- Yes, according to the manual: Vendor claim: peptide sequences through FASTA and HELM. Opens the cited page.ACD/ChemSketchVendor claim: peptide sequences through FASTA and HELM.Source
- Yes, according to the manual: One-letter peptide sequences; bounded native-17 residue profile with zwitterionic termini. Opens the cited page.Ferrum Chemical ForgeOne-letter peptide sequences; bounded native-17 residue profile with zwitterionic termini.Source
- Yes, according to the manual: vendor claim; peptide sequence import. Opens the cited page.Marvin Cloudvendor claim; peptide sequence import.Source
- Yes, according to the manual: Protein, gene, RNA and DNA sequences; FASTA input/output. Opens the cited page.JSDrawProtein, gene, RNA and DNA sequences; FASTA input/output.Source
Not available
- No: Biological sequence and monomer assembly workflows are missing. Opens the cited page.ReShikiBiological sequence and monomer assembly workflows are missing.Source
- No: Ketcher's macromolecule editor is explicitly disabled. Opens the cited page.ChemThisTryKetcher's macromolecule editor is explicitly disabled.Source
- No: Official comparison explicitly excludes biopolymer tools. Opens the cited page.MolChartOfficial comparison explicitly excludes biopolymer tools.Source
- No: Dedicated macromolecule authoring is explicitly disabled. Opens the cited page.MolbrettDedicated macromolecule authoring is explicitly disabled.Source
- No: Biomacromolecules are explicitly outside the supported scope. Opens the cited page.Molecule Builder (OvOHongYu)Biomacromolecules are explicitly outside the supported scope.Source
- No: Biopolymer expansion unimplemented. Opens the cited page.ChemifreeBiopolymer expansion unimplemented.Source
- No: Sequence mode explicitly excluded from v1. Opens the cited page.schematicSequence mode explicitly excluded from v1.Source
Not established (87)
ChemDraft, SketchIQ, Covalent, Reactio Draw, Molecule Lab (The Freshman Mole), ErezDraw, Chemliora, Zeanium Molecule Drawer, Sciformation VectorMol, ChemDoodle Web Components, MoleditPy, ChemCanvas, MolView.com, OpenReactions, PyChem-Pro, chemfig, KetchDraw, Chemvas, Molsketch, Chemable, WaveSpeed AI Chemical Structure Drawer, cDraw, JChemPaint, Molsoft HTML5 Molecule Editor, Molecule Clipboard, MolGLideX, SketchScape, ChemSema, Structura (chem-structura), OpenChemLib JS editor, MolSketch, SketchEl 2, Kekule.js, SketchEl, RadSketch, Butlerov, ChemMD, WebMolKit, rdEditor, ChemCanvasJS, Chemical Structure Editor (CSE), Kemia, JMolDraw, MolTouch, Chemeditor (Chemie-Lernprogramme), SketChem, vue-chemdraw (0chem), ChemWriter, MCDL Java Chemical Structure Editor, Glass, molsketch-cljs, MolPad, BKChem Python 3 Modernized, ChemDraft (元素智研), BKChem, ChemWindow (KnowItAll ChemWindow Edition), GChemPaint, KingDraw, ChemPencil, Chem4Word, AtomLens, Chemtool, Lhendraw, ChemCAD, MoleculeSketch, FX ChemStruct / FX Draw Chemical Structures, Chemistry 4-D Draw, ChemStitch, BondDraw, ChemGraphic 2, EasyChem, MolSketchGo, MyChemise, CyBy-Draw, Elk_Draw RDKit, Chem+ Molecular Structure Editor, MolPrime+, MolGenDraw, Chirys Draw, ChemScribble, Chem Sketcher (Non_REM.Persona Laboratory), Structo, Chemograph Plus, alvaSketcher, moled, ChemWorks, Molecule