R-groups and query structures

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• Yes, according to the manual: R positions, variable bond orders and atom lists. Opens the cited page.ChemDrawR positions, variable bond orders and atom lists.
• Partly: Finite element/group alternatives; general query predicates and R-logic remain unsupported. Opens the cited page.ReShikiFinite element/group alternatives; general query predicates and R-logic remain unsupported.Source
• Yes, according to the manual: Supports R, R1, and R2 atom labels. Opens the cited page.MolDrawSupports R, R1, and R2 atom labels.Source
• Yes, according to the manual: MDL R-groups, generic atoms and chemical query atom lists. Opens the cited page.PenzeneMDL R-groups, generic atoms and chemical query atom lists.Source
• Yes, according to the manual: Supports R-group definitions, atom lists and query properties. Opens the cited page.Octet DrawSupports R-group definitions, atom lists and query properties.Source
• Yes, according to the manual: R-group and generic placeholders; no formula contribution. Opens the cited page.ChemDraftR-group and generic placeholders; no formula contribution.Source
• Yes, according to the manual: R-groups are available from the toolbars. Opens the cited page.SketchIQR-groups are available from the toolbars.Source
• Yes, according to the manual: R-group lists, enumeration and decomposition. Opens the cited page.Reactio DrawR-group lists, enumeration and decomposition.Source
• Yes, according to the manual. Opens the cited page.ChemEditSource
• Yes, according to the manual. Opens the cited page.Chem IllustratorSource
• Yes, according to the manual: Sketcher provides generic R-group markers and reaction mapping. Opens the cited page.ChemThisTrySketcher provides generic R-group markers and reaction mapping.Source
• Yes, according to the manual: Supports atom lists, wildcards, Markush and R-group query data. Opens the cited page.Chematic DrawSupports atom lists, wildcards, Markush and R-group query data.Source
• Yes, according to the manual: Embedded Ketcher supports R-groups, attachment points and R-group logic. Opens the cited page.FreeChemDrawEmbedded Ketcher supports R-groups, attachment points and R-group logic.Source
• Yes, according to the manual: R-group cores, substituent definitions and R-logic. Opens the cited page.vibe-sketcherR-group cores, substituent definitions and R-logic.Source
• Yes, according to the manual: R-group and halide placeholder atom labels. Opens the cited page.MolChartR-group and halide placeholder atom labels.Source
• Yes, according to the manual: R-groups, attachment points and query atoms. Opens the cited page.KendrawR-groups, attachment points and query atoms.Source
• Yes, according to the manual: Ketcher supports R-groups, atom lists, and attachment logic. Opens the cited page.MolbrettKetcher supports R-groups, atom lists, and attachment logic.Source
• Yes, according to the manual: Toolbar provides R-group and wildcard atom choices. Opens the cited page.Sciformation VectorMolToolbar provides R-group and wildcard atom choices.Source
• Yes, according to the manual: Query atoms support element lists, wildcards, and attachment constraints. Opens the cited page.ChemDoodle Web ComponentsQuery atoms support element lists, wildcards, and attachment constraints.Source
• Yes, according to the manual: Ketcher supports R-groups, atom lists and Markush logic. Opens the cited page.Chemeditor (Chemrise)Ketcher supports R-groups, atom lists and Markush logic.Source
• Yes, according to the manual: R-group atom labels, including optional numbering. Opens the cited page.MolView.comR-group atom labels, including optional numbering.Source
• Yes, according to the manual: R-groups, atom lists, attachment points and R-group logic. Opens the cited page.KetcherR-groups, atom lists, attachment points and R-group logic.Source
• Yes, according to the manual: Ketcher supports R-group labels, fragments, attachment points and logic. Opens the cited page.AI Chemical Drawing (CubicZnS)Ketcher supports R-group labels, fragments, attachment points and logic.Source
• Partly: R atom tool appears; query behavior unverified. Opens the cited page.OpenReactionsR atom tool appears; query behavior unverified.
• Yes, according to the manual. Opens the cited page.KetchDrawSource
• Yes, according to the manual: Explicit generic-aryl bindings export native CDXML queries. Opens the cited page.ChemvasExplicit generic-aryl bindings export native CDXML queries.Source
• Yes, according to the manual: R-groups, element lists and query constraints. Opens the cited page.Schrödinger SketcherR-groups, element lists and query constraints.Source
• Yes, according to the manual: R-group queries, attachment points, logic and enumeration. Opens the cited page.JChemPaintR-group queries, attachment points, logic and enumeration.Source
• Yes, according to the manual: R-group labels and hydrogen, connectivity and ring query constraints. Opens the cited page.Molsoft HTML5 Molecule EditorR-group labels and hydrogen, connectivity and ring query constraints.Source
• Yes, according to the manual: Query drawing enabled in embedded JSME. Opens the cited page.Molecule ClipboardQuery drawing enabled in embedded JSME.Source
• Partly: R-label insertion only; no R-group definitions or atom lists. Opens the cited page.MolGLideXR-label insertion only; no R-group definitions or atom lists.Source
• Yes, according to the manual: Editable element lists, generic lists, and atom-query properties. Opens the cited page.ChemSemaEditable element lists, generic lists, and atom-query properties.Source
• Yes, according to the manual: Variable definitions and enumeration UI live in the separate app workspace. Opens the cited page.Structura (chem-structura)Variable definitions and enumeration UI live in the separate app workspace.Source
• Yes, according to the manual: Fragment mode supports atom lists through query-feature dialogs. Opens the cited page.OpenChemLib JS editorFragment mode supports atom lists through query-feature dialogs.Source
• Yes, according to the manual: R-group definitions, attachment points, logic, and atom lists. Opens the cited page.Dotmatics Elemental / Elemental DrawR-group definitions, attachment points, logic, and atom lists.Source
• Yes, according to the manual: Atom lists, exclusions, and other chemical query constraints. Opens the cited page.SketchEl 2Atom lists, exclusions, and other chemical query constraints.Source
• Yes, according to the manual: R-group nodes and allowed or disallowed atom lists. Opens the cited page.Kekule.jsR-group nodes and allowed or disallowed atom lists.Source
• Yes, according to the manual: R-group labels and editable atom/bond query properties. Opens the cited page.SketchElR-group labels and editable atom/bond query properties.Source
• Yes, according to the manual: Element-list and generic query atoms; substructure matching supported. Opens the cited page.ChemifreeElement-list and generic query atoms; substructure matching supported.Source
• Yes, according to the manual: R-group labels, fragments and attachment points. Opens the cited page.Ketcherails (ketcher-rails)R-group labels, fragments and attachment points.Source
• Yes, according to the manual: Query atom lists and excluded elements. Opens the cited page.WebMolKitQuery atom lists and excluded elements.Source
• Yes, according to the manual: Simple numbered R-group dummy atoms; full Markush authoring unverified. Opens the cited page.rdEditorSimple numbered R-group dummy atoms; full Markush authoring unverified.Source
• Partly: R1 placement adds accessible label; drawing clipped. Opens the cited page.KemiaR1 placement adds accessible label; drawing clipped.Source
• Yes, according to the manual: Query Atom editor supports atom lists and Beilstein generic groups. Opens the cited page.JMolDrawQuery Atom editor supports atom lists and Beilstein generic groups.Source
• Partly: Numbered R-label import only; atom-list handling unfinished. Opens the cited page.vue-chemdraw (0chem)Numbered R-label import only; atom-list handling unfinished.Source
• Yes, according to the manual: Atom lists, wildcard bonds and numbered R-groups; host-configurable. Opens the cited page.ChemWriterAtom lists, wildcard bonds and numbered R-groups; host-configurable.Source
• Yes, according to the manual: Query atoms support R, A, Q, X and element lists. Opens the cited page.BKChem Python 3 ModernizedQuery atoms support R, A, Q, X and element lists.Source
• Yes, according to the manual: R/R1/R2 aliases and generic query bond tools. Opens the cited page.LabCanvas Figure Editor / MolDrawR/R1/R2 aliases and generic query bond tools.Source
• Yes, according to the manual. Opens the cited page.Marvin Desktop Suite / MarvinSketchSource
• Partly: Markush attachment markers documented; full R-group/query handling unverified. Opens the cited page.ChemDraft (元素智研)Markush attachment markers documented; full R-group/query handling unverified.Source
• Yes, according to the manual. Opens the cited page.InDrawSource
• Yes, according to the manual: R-groups, definitions, R-logic and atom lists. Opens the cited page.Marvin JSR-groups, definitions, R-logic and atom lists.Source
• Yes, according to the manual: Atom lists and A/Q/X/R query atoms. Opens the cited page.BKChemAtom lists and A/Q/X/R query atoms.Source
• Yes, according to the manual: vendor claim; R-group queries and variable attachments. Opens the cited page.BIOVIA Drawvendor claim; R-group queries and variable attachments.Source
• Yes, according to the manual: Numbered R-groups act as variable groups in structure searches. Opens the cited page.ChemWindow (KnowItAll ChemWindow Edition)Numbered R-groups act as variable groups in structure searches.Source
• Yes, according to the manual. Opens the cited page.Chemistry DrawSource
• Yes, according to the manual. Opens the cited page.Zoho ChemStudioSource
• Yes, according to the manual: Generic R, Ar, X and M residues. Opens the cited page.GChemPaintGeneric R, Ar, X and M residues.Source
• Yes, according to the manual: Query atoms, atom lists and SMARTS; vendor claim. Opens the cited page.ChemPencilQuery atoms, atom lists and SMARTS; vendor claim.Source
• Yes, according to the manual: R-groups, positional variants, and structure enumeration. Opens the cited page.ACD/ChemSketchR-groups, positional variants, and structure enumeration.Source
• Yes, according to the manual: Markush structures, R-groups and query properties. Opens the cited page.Marvin CloudMarkush structures, R-groups and query properties.Source
• Yes, according to the manual: R-group residue labels include R1, R2, and numbered variants. Opens the cited page.Chem4WordR-group residue labels include R1, R2, and numbered variants.Source
• Yes, according to the manual: Markush scaffolds, R-group legends, and supported query annotations. Opens the cited page.AtomLensMarkush scaffolds, R-group legends, and supported query annotations.Source
• Yes, according to the manual: Periodic-table palette includes chemical wildcards. Opens the cited page.LhendrawPeriodic-table palette includes chemical wildcards.Source
• Yes, according to the manual: Editable R-group definitions and alternative substructures. Opens the cited page.JSDrawEditable R-group definitions and alternative substructures.Source
• Yes, according to the manual: Supports R and R-prime groups in structures. Opens the cited page.FX ChemStruct / FX Draw Chemical StructuresSupports R and R-prime groups in structures.Source
• Yes, according to the manual: Numbered R-group attachment labels. Opens the cited page.BondDrawNumbered R-group attachment labels.Source
• Yes, according to the manual: Vendor claim: R-groups supported, including MOL import. Opens the cited page.Chirys DrawVendor claim: R-groups supported, including MOL import.Source

Not available

• No: No query atoms, alternative groups or generic matching rules. Opens the cited page.ErezDrawNo query atoms, alternative groups or generic matching rules.Source
• No: Query atoms explicitly cannot be represented. Opens the cited page.MolCanvasQuery atoms explicitly cannot be represented.Source