SMILES

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• Yes, tested by running it: Pasted fixture SMILES; copied caffeine back as SMILES. Opens the cited page.ChemDrawPasted fixture SMILES; copied caffeine back as SMILES.
• Yes, tested by running it: Imported fixtures; copied caffeine SMILES and verified pasted text. Opens the cited page.PenzeneUses RDKit SmilesParse and SmilesWrite (C++). Imported fixtures; copied caffeine SMILES and verified pasted text.Source
• Yes, tested by running it: Pasted all three fixtures; exported caffeine SMILES. Opens the cited page.Octet DrawUses Indigo (WebAssembly). Pasted all three fixtures; exported caffeine SMILES.Source
• Yes, tested by running it: Pasted fixtures and copied caffeine SMILES. Opens the cited page.CovalentUses In-house parseSmiles and writeSmiles (JavaScript parser, canonicalizer and writer modules in browser). Pasted fixtures and copied caffeine SMILES.Source
• Yes, tested by running it: Imported fixtures and saved generated Daylight SMILES. Opens the cited page.ChemEditUses Indigo 1.45.1 (C++ compiled to WebAssembly, SMILES import/export via Ketcher); OpenChemLib JS 9.25.0 (SMILES parsing and MOL-to-SMILES helper). Imported fixtures and saved generated Daylight SMILES.Source
• Yes, tested by running it: Pasted SMILES and copied ethanol as CCO. Opens the cited page.Chem IllustratorUses RDKit MinimalLib 2026.9.1 (WebAssembly SMILES parser and writer, local worker). Pasted SMILES and copied ethanol as CCO.Source
• Partly: Paste and export worked; cholesterol export lost stereochemistry. Opens the cited page.Chematic DrawUses In-house (chematic-smiles, Rust/WebAssembly parser and standard/canonical writers). Paste and export worked; cholesterol export lost stereochemistry.Source
• Partly: PubChem-backed SMILES import and lookup output worked. Opens the cited page.Molecule Lab (The Freshman Mole)Uses PubChem web service (server-proxied import and record lookup); Kekule.js (JavaScript writer fallback). PubChem-backed SMILES import and lookup output worked.Source
• Partly: Paclitaxel imports correctly; caffeine becomes +3. No SMILES export. Opens the cited page.ErezDrawUses RDKit (Python Chem.MolFromSmiles import); output limited to PubChem-matched properties. Paclitaxel imports correctly; caffeine becomes +3. No SMILES export.Source
• Yes, tested by running it: Imported SMILES and copied indole SMILES. Opens the cited page.MolChartUses OpenChemLib (browser JavaScript Molecule.fromSmiles/toSmiles). Imported SMILES and copied indole SMILES.Source
• Yes, tested by running it: Imported SMILES and exported Daylight SMILES through Ketcher. Opens the cited page.KendrawUses Indigo WebAssembly through Ketcher; RDKit native Python bindings for backend conversion; In-house TypeScript import parser. Imported SMILES and exported Daylight SMILES through Ketcher.Source
• Yes, tested by running it: SMILES imported and output previews generated for three fixtures. Opens the cited page.MolbrettUses Indigo 1.46.0 (WebAssembly, Ketcher standalone browser worker). SMILES imported and output previews generated for three fixtures.Source
• Partly: Read and copied SMILES; importer discards stereochemistry. Opens the cited page.Zeanium Molecule DrawerUses In-house (JavaScript parser/writer; stereo and isotopes omitted). Read and copied SMILES; importer discards stereochemistry.Source
• Partly: Import/export works; cholesterol loses all eight assigned stereocenters. Opens the cited page.BondForgeUses RDKit (Python). Import/export works; cholesterol loses all eight assigned stereocenters.Source
• Yes, tested by running it: Separate SMILES demo read caffeine and wrote imported structures. Opens the cited page.ChemDoodle Web ComponentsUses ChemDoodle Java API (remote iChemLabs CloudServices; readSMILES and writeSMILES). Separate SMILES demo read caffeine and wrote imported structures.Source
• Yes, tested by running it: Opened SMILES; generated SMILES shown in save preview. Opens the cited page.Chemeditor (Chemrise)Uses Indigo (WebAssembly through ketcher-standalone). Opened SMILES; generated SMILES shown in save preview.Source
• Yes, tested by running it: Imported and exported SMILES. Opens the cited page.KetcherUses Indigo C++ conversion/layout (indigo-ketcher WebAssembly or Indigo HTTP service). Imported and exported SMILES.Source
• Yes, tested by running it: Imported SMILES and saved Daylight SMILES. Opens the cited page.AI Chemical Drawing (CubicZnS)Uses Indigo 1.46.0 (WebAssembly). Imported SMILES and saved Daylight SMILES.Source
• Yes, tested by running it: Imported SMILES and copied generated SMILES. Opens the cited page.OpenReactionsUses OpenChemLib (JavaScript). Imported SMILES and copied generated SMILES.Source
• Yes, tested by running it: Imported and exported SMILES. Opens the cited page.KetchDrawUses Indigo (WebAssembly). Imported and exported SMILES.Source
• Partly: Imported both fixtures; paclitaxel round-trip altered stereochemistry. Opens the cited page.MolsketchUses Open Babel SMILES format plugin (native C++ through optional obabeliface shared library). Imported both fixtures; paclitaxel round-trip altered stereochemistry.Source
• Partly: Imported and exported all fixtures; stereochemistry markers were lost. Opens the cited page.ChemableUses In-house (TypeScript SMILES export without stereochemistry); RDKit (local Python/PyInstaller sidecar for SMILES import). Imported and exported all fixtures; stereochemistry markers were lost.Source
• Yes, tested by running it: Loaded SMILES and exported canonical SMILES. Opens the cited page.WaveSpeed AI Chemical Structure DrawerUses RDKit.js (WebAssembly). Loaded SMILES and exported canonical SMILES.Source
• Partly: Both fixtures imported; output failed because JNI-InChI library was missing. Opens the cited page.cDrawUses Ported from CDK SmilesParser/CDKToBeam/InChINumbersTools (Java); Beam 1.3.2 (bundled Java); JNI-InChI 0.7 (local native canonical numbering); MCDL 1.00 (bundled Java coordinate generation). Both fixtures imported; output failed because JNI-InChI library was missing.Source
• Partly: Caffeine paste and generation worked; paclitaxel file autodetection failed. Opens the cited page.JChemPaintUses CDK SmilesParser, SMILESReader, SmilesGenerator and SMILESWriter (Java). Caffeine paste and generation worked; paclitaxel file autodetection failed.Source
• Partly: SMILES inputs remained empty; canonical output command produced no verified text. Opens the cited page.MolGLideXUses CDK (Java SmilesGenerator, canonical output only). SMILES inputs remained empty; canonical output command produced no verified text.Source
• Partly: SMILES copy command reported success; SMILES files failed to open. Opens the cited page.ChemSemaUses Ported from RDKit (grammar and lexer reimplemented in Rust; ChemSema parser and writer). SMILES copy command reported success; SMILES files failed to open.Source
• Partly: SMILES output worked; MOL paste box did not accept SMILES. Opens the cited page.Dotmatics Elemental / Elemental DrawSMILES output worked; MOL paste box did not accept SMILES.
• Partly: SMILES export worked; load dialog lacks SMILES format. Opens the cited page.Kekule.jsUses In-house (JavaScript SMILES writer); Indigo or Open Babel (optional C++ compiled to WebAssembly readers). SMILES export worked; load dialog lacks SMILES format.Source
• Partly: Fixture imports and writes work; directional stereo is refused. Opens the cited page.ChemifreeUses In-house (Rust OpenSmilesCodec; bounded SMILES reader and writers). Fixture imports and writes work; directional stereo is refused.Source
• Partly: SMILES output worked; SMILES imports produced no drawing. Opens the cited page.Ketcherails (ketcher-rails)Uses Ketcher (bundled JavaScript; export only). SMILES output worked; SMILES imports produced no drawing.Source
• Partly: SMILES paste works; no output command; chirality not depicted. Opens the cited page.schematicUses In-house (TypeScript SMILES subset parser; import only). SMILES paste works; no output command; chirality not depicted.Source
• Yes, tested by running it: Pasted fixtures and saved caffeine SMILES successfully. Opens the cited page.rdEditorUses RDKit (Python). Pasted fixtures and saved caffeine SMILES successfully.Source
• Partly: Separate demo accepts SMILES; no output command; drawing clipped. Opens the cited page.KemiaUses In-house. Separate demo accepts SMILES; no output command; drawing clipped.Source
• Partly: Caffeine SMILES exported; pasted SMILES displayed blank. Opens the cited page.SketChemUses Kekule.js (JavaScript writer); Indigo (WebAssembly reader). Caffeine SMILES exported; pasted SMILES displayed blank.Source
• Yes, according to the manual: Read/write implemented; legacy UI warnings conflict with bundled parser capabilities. Opens the cited page.BKChem Python 3 ModernizedUses OASA (bundled Python SMILES parser and writer). Read/write implemented; legacy UI warnings conflict with bundled parser capabilities.Source
• Yes, according to the manual. Opens the cited page.ChemDoodle 2DUses In-house (ChemDoodle Java file-format interpreters, local). Source
• Yes, according to the manual: Paste SMILES and read drawing SMILES; file exports require Pro. Opens the cited page.LabCanvas Figure Editor / MolDrawUses In-house (JavaScript native SMILES parser/writer); optional Indigo (WebAssembly conversion/layout). Paste SMILES and read drawing SMILES; file exports require Pro.Source
• Yes, according to the manual. Opens the cited page.Marvin Desktop Suite / MarvinSketchUses In-house Chemaxon I/O SMILES module (local Java MolImporter/MolExporter). Source
• Yes, according to the manual: Clipboard export; import through Special Paste in section 11.3. Opens the cited page.ChemDraft (元素智研)Uses RDKit SmilesWrite (vendor SciRDKit C++ compiled to browser WebAssembly; confirmed SMILES clipboard export). Clipboard export; import through Special Paste in section 11.3.Source
• Yes, according to the manual: Bundled InTable reads and generates SMILES. Opens the cited page.InDrawUses RDKit.js (browser WebAssembly SMILES import); Ported from Ketcher (bundled JavaScript SmilesGenerator export). Bundled InTable reads and generates SMILES.Source
• Yes, according to the manual: SMILES import and export require conversion web services. Opens the cited page.Marvin JSUses In-house Chemaxon MolConvert (remote Java REST service via MJSWS, JChem Web Services or JChem Microservices; molconvertws). SMILES import and export require conversion web services.Source
• Yes, according to the manual: Imports a SMILES subset and generates SMILES. Opens the cited page.BKChemUses OASA (Python SMILES parser/writer and coordinate generator). Imports a SMILES subset and generates SMILES.Source
• Yes, according to the manual: vendor claim; SMILES conversion in both directions. Opens the cited page.BIOVIA Drawvendor claim; SMILES conversion in both directions.Source
• Yes, according to the manual: SMILES/MOL round trips and canonical SMILES output. Opens the cited page.Chemistry DrawUses Indigo (native C++ via Rust FFI; SMILES loading and canonical SMILES output). SMILES/MOL round trips and canonical SMILES output.Source
• Yes, according to the manual. Opens the cited page.Zoho ChemStudioSource
• Partly: Canonical SMILES generation documented; direct import unverified. Opens the cited page.GChemPaintUses Open Babel (C++ library in local babelserver helper; canonical SMILES export). Canonical SMILES generation documented; direct import unverified.Source
• Yes, according to the manual: Copy As exports; Paste Special imports. Opens the cited page.KingDrawCopy As exports; Paste Special imports.Source
• Yes, according to the manual. Opens the cited page.ChemPencilSource
• Yes, according to the manual: Vendor claim: SMILES input and output. Opens the cited page.ACD/ChemSketchVendor claim: SMILES input and output.Source
• Yes, according to the manual: SMILES conversion input and output through the local chemistry runtime. Opens the cited page.Ferrum Chemical ForgeUses RDKit (C++). SMILES conversion input and output through the local chemistry runtime.Source
• Yes, according to the manual: SMILES import and export; CXSMILES also supported. Opens the cited page.Marvin CloudUses In-house Marvin Web Services MolConvert (remote Java service). SMILES import and export; CXSMILES also supported.Source
• Partly: SMILES output via online service; native import accepts CML/MOL/SDF/SketchEl. Opens the cited page.Chem4WordUses Chem4Word ChemicalServices Resolve API (remote server; SMILES output; underlying engine undisclosed). SMILES output via online service; native import accepts CML/MOL/SDF/SketchEl.Source
• Yes, according to the manual: Standard and isomeric SMILES; export excludes CXSMILES extensions. Opens the cited page.AtomLensUses CDKSwiftNativePort (native Swift CDK SMILES/CXSMILES parser and SMILES writer). Standard and isomeric SMILES; export excludes CXSMILES extensions.Source
• Yes, according to the manual: Import requires Web Services; SMILES export is documented in SDK. Opens the cited page.JSDrawUses In-house (JavaScript export); JSDraw Web Services (remote server import). Import requires Web Services; SMILES export is documented in SDK.Source
• Yes, according to the manual: Canonical SMILES copy and editable structure paste. Opens the cited page.ChemCADUses RDKit (native C++ SmilesToMol parser and MolToSmiles writer). Canonical SMILES copy and editable structure paste.Source
• Yes, according to the manual: SMILES import and clipboard export. Opens the cited page.ChemStitchSMILES import and clipboard export.Source
• Partly: Subset reads/writes; @/@@ unsupported and exported stereochemistry omitted. Opens the cited page.BondDrawUses In-house (C++ libjcp_engine.so via N-API; SMILES subset). Subset reads/writes; @/@@ unsupported and exported stereochemistry omitted.Source
• Partly: SMILES import; export formats list omits SMILES. Opens the cited page.ChemGraphic 2SMILES import; export formats list omits SMILES.Source
• Yes, according to the manual: SMILES import/export; vendor claim. Opens the cited page.MolSketchGoSMILES import/export; vendor claim.Source
• Partly: SMILES import; export paths provide SVG or MOL text. Opens the cited page.CyBy-DrawUses idris2-chem (Idris chem package, SMILES import and Geom.Gen2D coordinates). SMILES import; export paths provide SVG or MOL text.Source
• Yes, according to the manual: SMILES input files and calculated SMILES output; vendor claim. Opens the cited page.Elk_Draw RDKitSMILES input files and calculated SMILES output; vendor claim.Source
• Partly: Pro; vendor claim: SMILES export; import undocumented. Opens the cited page.Chem+ Molecular Structure EditorProUses Indigo (browser WebAssembly through Ketcher standalone). Pro; vendor claim: SMILES export; import undocumented.Source
• Yes, according to the manual: Reads/writes SMILES, including multi-record SMI collections. Opens the cited page.MolGenDrawUses RDKit (Python Chem.MolFromSmiles and MolToSmiles). Reads/writes SMILES, including multi-record SMI collections.Source
• Partly: Clipboard export only; chemical text cannot be imported. Opens the cited page.ChemScribbleClipboard export only; chemical text cannot be imported.Source
• Yes, according to the manual: Vendor claim: SMILES import and export. Opens the cited page.StructoVendor claim: SMILES import and export.Source
• Partly: vendor claim; SMILES clipboard output confirmed; import unverified. Opens the cited page.alvaSketchervendor claim; SMILES clipboard output confirmed; import unverified.Source
• Partly: Source parser only; editor input hardcoded, export unverified. Opens the cited page.moledUses Smidge (JavaScript). Source parser only; editor input hardcoded, export unverified.Source

Not available

• No: Opening caffeine SMILES file left canvas empty. Opens the cited page.Sciformation VectorMolOpening caffeine SMILES file left canvas empty.
• No: Direct SMILES produced overlapping labels; external conversion required. Opens the cited page.chemfigDirect SMILES produced overlapping labels; external conversion required.
• No: Paste timed out; canvas stayed empty; no SMILES import command. Opens the cited page.ChemvasPaste timed out; canvas stayed empty; no SMILES import command.Source
• No: Caffeine SMILES paste rejected as unrecognisable molecule. Opens the cited page.SketchEl 2Caffeine SMILES paste rejected as unrecognisable molecule.
• No: Fixture input left blank canvases; drawn ethene output string empty. Opens the cited page.XDrawChemFixture input left blank canvases; drawn ethene output string empty.Source
• No: SMILES file import failed; paste also failed to produce a structure. Opens the cited page.SketchElSMILES file import failed; paste also failed to produce a structure.
• No: Pasted caffeine and paclitaxel SMILES rejected. Opens the cited page.ChemMDPasted caffeine and paclitaxel SMILES rejected.Source
• No: SMILES paste rejected; no SMILES export control found. Opens the cited page.WebMolKitSMILES paste rejected; no SMILES export control found.Source
• No: SMILES file rejected; no paste field found. Opens the cited page.ChemCanvasJSSMILES file rejected; no paste field found.Source
• No: SMILES paste produced no drawing; no SMILES export found. Opens the cited page.Chemical Structure Editor (CSE)SMILES paste produced no drawing; no SMILES export found.
• No: Opening simple.smi failed: Cannot read field x because vec2 is null. Opens the cited page.JMolDrawOpening simple.smi failed: Cannot read field x because vec2 is null.
• No: SMILES file displayed as text without a structure. Opens the cited page.MolTouchSMILES file displayed as text without a structure.
• No: SMILES input remained literal text; no chemistry conversion. Opens the cited page.Chemeditor (Chemie-Lernprogramme)SMILES input remained literal text; no chemistry conversion.
• No: SMILES in MOL input did not produce a structure. Opens the cited page.vue-chemdraw (0chem)SMILES in MOL input did not produce a structure.
• No: Caffeine SMILES rejected; export dialog offers MOL text. Opens the cited page.ChemWriterCaffeine SMILES rejected; export dialog offers MOL text.Source
• No: Both fixture SMILES pastes left the canvas empty. Opens the cited page.MCDL Java Chemical Structure EditorBoth fixture SMILES pastes left the canvas empty.
• No: SMILES import and export failed. Opens the cited page.GlassSMILES import and export failed.Source
• No: Pasting fixture SMILES did not import a structure. Opens the cited page.molsketch-cljsPasting fixture SMILES did not import a structure.
• No: Simulated SMILES paste produced no structure; no import control. Opens the cited page.MolPadSimulated SMILES paste produced no structure; no import control.